Atherogenic Dyslipidemia: Cardiovascular Risk and Dietary Intervention |
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Authors: | Kiran Musunuru |
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Affiliation: | (1) Cardiology Division, Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St CPZN 5th floor, Boston, MA 02114, USA |
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Abstract: | Atherogenic dyslipidemia comprises a triad of increased blood concentrations of small, dense low-density lipoprotein (LDL)
particles, decreased high-density lipoprotein (HDL) particles, and increased triglycerides. A typical feature of obesity,
the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus, atherogenic dyslipidemia has emerged as an important
risk factor for myocardial infarction and cardiovascular disease. A number of genes have now been linked to this pattern of
lipoprotein changes. Low-carbohydrate diets appear to have beneficial lipoprotein effects in individuals with atherogenic
dyslipidemia, compared to high-carbohydrate diets, whereas the content of total fat or saturated fat in the diet appears to
have little effect. Achieving a better understanding of the genetic and dietary influences underlying atherogenic dyslipidemia
may provide clues to improved interventions to reduce the risk of cardiovascular disease in high-risk individuals. |
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