克罗诺杆菌主要毒力因子及致病机理研究进展

综述了克罗诺杆菌肠毒素、外膜蛋白、基因Inv、关键酶RpfF等主要的毒力因子在克罗诺杆菌致病过程中的作用,并从菌毛的黏附作用、克罗诺杆菌对铁的吸收作用、对唾液酸的利用能力、生物膜对克罗诺杆菌的保护作用和黏附能力的影响、外排系统对克罗诺杆菌在宿主胃肠道中存活能力的影响、耐干燥能力等几个方面总结了该病原菌的致病机理。

Progress on main virulence factors and pathogenic mechanism of Cronobacter spp.

In this study, the role of major virulence factors in the pathogenic process of Cronobacter, including enterotoxin, outer membrane protein, gene Inv, and key enzyme RpfF were reviewed. Furthermore, the pathogenic mechanism was summarized from the following aspects, i. e. the adhesion of bacterial hair, the absorption ability of iron by Cronobacter, the utilization of sialic acid, the effects of biofilm on the protection, and the adhesion of Cronobacter, the effect of efflux system on the viability of Cronobacter in host gastrointestinal tract and desiccation resistance.