Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

Various approaches have been proposed for point-of-care diagnostics,and in particular,optical detection is preferred because it is relatively simple and fast.At the same time,field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection.In this work we present highly sensitive,epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors,read-out circuits,and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA).Regardless of the physical forms or mechanical stress conditions,our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg.mL-1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM)and tapping-mode atomic force microscopy (tm-AFM).Furthermore,current modulation induced by the binding process was stably maintained for longer than 2-3 min.The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.