Poly‐D,L‐lactide and levofloxacin‐blended beads: A sustained local releasing system to treat osteomyelitis |
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| Authors: | Hong Cao Liao‐bin Chen Yan‐song Liu Han Xiu Hui Wang |
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| Affiliation: | 1. Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, People's Republic of China;2. Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, People's Republic of China;3. Department of Pharmacology, Basic Medical School, Wuhan University, Wuhan 430071, People's Republic of China |
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| Abstract: | Osteomyelitis is the inflammation of bone which is treated by a high dose of antibiotics given intravenously for 4–6 weeks. However, at present locally administered antibiotic such as gentamicin poly (methyl methacrylate) (PMMA) bead is nonbiodegradable and a secondary surgery is often inevitable. This study described the biodegradable material poly‐D , L ‐lactide (PLA) with 80 kDa molecular weight that could be used as a potential antibiotic carrier for local drug release. PLA was first dissolved in tetrahydrofuran followed by blending with levofloxacin (LFX) in a physical way. The blend was then molded into beads. The optimized weight ratio between PLA and LFX was designated as 45 : 15. Glass transition temperature and surface ultramicrostructure of the beads were measured. In vitro tests of drug release and bacteriostasis demonstrated that the PLA–LFX beads released high concentrations of antibiotic for the period of time (i.e., 6 weeks), which is needed to treat bone infection. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 |
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| Keywords: | poly‐D l‐lactide levofloxacin osteomyelitis sustained delivery system |
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