在串联的半间歇搅拌釜式反应器中丙酮氯化反应的研究

一、前言由于丙酮分子中α碳上氢原子受羰基的影响,容易被氯原子取代,因此,氯化丙酮的制备即采用丙酮直接氯化的途径。1,1,3-三氯丙酮是生产叶酸的重要原料。目前国内制药厂是采用四个串联的200 L 搪瓷反应釜,在不带机械搅拌的半间歇或半流动条件下,进行丙酮氯化生产1,1,3-三氯丙酮。其操作特点是,丙酮一次性加入反应釜,因氯气在丙酮及氯化丙酮中是不易溶解的气体,所以氯气加入量的速率仅能按在反应温度下的溶解度而定,不仅

A STUDY ON THE CHLORINATION OF ACETONE IN A CASCADE OF SEMI-BATCH STIRRED REACTORS

1,1,3-Trichloroacetone was prepared by chlorination of acetone with chlorine in a cascade of four semi-batch stirred reactors.It was found that the yield of 1,1,3-trichloroacetone decreases and that of polychloroacetone increases tepidly with the increase of the number of reactors.In order to give good yield of 1,1,3-trichloroacetone and to depress the formation of by-product polychloroacetone,a cascade consisting of two stirred semi-batch reactors is of the relevant choice.