Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass |
| |
Authors: | Bojan Čalija Jela Milić Nikola Milašinović Aleksandra Daković Kata Trifković Jovica Stojanović Danina Krajišnik |
| |
Affiliation: | 1. Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221, Serbia;2. Department of Forensics, University of Criminal Investigation and Police Studies, 11080 Belgrade, Serbia Faculty of Technology and Metallurgy, Department of Chemical Engineering, University of Belgrade, 11000 Belgrade, Serbia;3. Institute for the Technology of Nuclear and Other Mineral Raw Materials, 11000 Belgrade, Serbia;4. Faculty of Technology and Metallurgy, Department of Chemical Engineering, University of Belgrade, 11000 Belgrade, Serbia |
| |
Abstract: | This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48406. |
| |
Keywords: | biopolymers and renewable polymers clay composites drug delivery systems films |
|
|