|
|||||
|
|
Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection |
|
| Authors: | Sang Ihn Han Sang-woo Lee Min Gee Cho Ji Mun Yoo Myoung Hwan Oh Beomgyun Jeong Dokyoon Kim Ok Kyu Park Junchul Kim Eun Namkoong Jinwoung Jo Nohyun Lee Chaehong Lim Min Soh Yung-Eun Sung Jongman Yoo Kyungpyo Park Taeghwan Hyeon |
| Affiliation: | 1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826 Republic of Korea School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826 Republic of Korea;2. Department of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, 03080 Republic of Korea;3. Advanced Nano Surface Research Group, Korea Basic Science Institute, Daejeon, 34133 Republic of Korea;4. Department of Bionano Engineering and Bionanotechnology, Hanyang University, Ansan, 15588 Republic of Korea;5. School of Advanced Materials Engineering, Kookmin University, Seoul, 136-702 Republic of Korea;6. Department of Microbiology, School of Medicine, CHA University, Sungnam, 13488 Republic of Korea;7. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826 Republic of Korea |
| Abstract: | Nanomaterials with antioxidant properties are promising for treating reactive oxygen species (ROS)-related diseases. However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications. Tuning the surface strain of metallic nanoparticles can enhance catalytic reactivity, which has rarely been demonstrated in metal oxide nanomaterials. Here, it is shown that inducing surface strains of CeO2/Mn3O4 nanocrystals produces highly catalytic antioxidants that can protect tissue-resident stem cells from irradiation-induced ROS damage. Manganese ions deposited on the surface of cerium oxide (CeO2) nanocrystals form strained layers of manganese oxide (Mn3O4) islands, increasing the number of oxygen vacancies. CeO2/Mn3O4 nanocrystals show better catalytic activity than CeO2 or Mn3O4 alone and can protect the regenerative capabilities of intestinal stem cells in an organoid model after a lethal dose of irradiation. A small amount of the nanocrystals prevents acute radiation syndrome and increases the survival rate of mice treated with a lethal dose of total body irradiation. |
| Keywords: | acute radiation syndrome heterostructured nanocrystals lattice strain radioprotectants reactive oxygen species |