New fatty acid derivatives from <Emphasis Type="Italic">Homaxinella</Emphasis> sp., a marine sponge |
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Authors: | Tayyab?A?Mansoor Bok?Hee?Bae Jongki?Hong Chong-O?Lee Kwang?Sik?Im Email author" target="_blank">Jee?H?JungEmail author |
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Affiliation: | (1) College of Pharmacy, Pusan National University, 609-735 Busan, Korea;(2) Kyung Hee University, 130-701 Seoul, Korea;(3) Korea Research Institute of Chemical Technology, 305-343 Daejon, Korea |
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Abstract: | Fractionation of the MeOH extract of Homaxinella sp., a marine sponge, led to the isolation of a sodium salt of a new brominated FA (1), two new MG (2 and 4), and a new lysoPC (6). The geometry of the double bonds in 1 and 2 was defined by comparison of the NMR chemical shifts of the allylic carbons, nuclear Overhauser effect spectroscopy correlations
of the allylic protons, and coupling constants of the vinylic protons with those reported. Evidence mainly from NMR and MS
analyses established the planar structures of the compounds. Compounds 1, 2, 4, and 6 were evaluated for cytotoxicity against a panel of five human solid tumor cell lines. Only compound 1 showed moderate activity. |
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