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NBS对芳香醚类化合物选择性溴代研究
引用本文:张月,刘亚军,金辉,王铨,张辉,许永男.NBS对芳香醚类化合物选择性溴代研究[J].辽宁化工,2012,41(10):1006-1007,1011.
作者姓名:张月  刘亚军  金辉  王铨  张辉  许永男
作者单位:沈阳药科大学制药工程学院,辽宁沈阳,110016
摘    要:2-(3,4-二甲氧基苯基)乙酸甲酯与N-溴代丁二酰亚胺(NBS)在摩尔比为1∶1,甲醇为溶剂,室温条件下反应,以94%的收率得到选择性好的芳环单溴代产物2-(2-溴-4,5-二甲氧基苯基)乙酸甲酯.其结构经1H NMR、MS谱确证.用温和的NBS作为溴代试剂避免了传统芳环溴代试剂强腐蚀性及强毒性的缺点,可发展为芳香醚类化合物溴代的一般方法.

关 键 词:芳香醚  N-溴代丁二酰亚胺(NBS)  溴代

Bromination of Aromatic Ethers by Using NBS as Brominating Agent
ZHANG Yue , LIU Ya-jun , JIN Hui , WANG Quan , ZHANG Hui , XU Yong-nan.Bromination of Aromatic Ethers by Using NBS as Brominating Agent[J].Liaoning Chemical Industry,2012,41(10):1006-1007,1011.
Authors:ZHANG Yue  LIU Ya-jun  JIN Hui  WANG Quan  ZHANG Hui  XU Yong-nan
Affiliation:(Shenyang Pharmaceutical University,Liaoning Shenyang 110016,China)
Abstract:Methyl 2-(2-bromo-4,5-dimethoxyphenyl)ethanoate was synthesized form methyl 2-(3,4-dimethoxyphenyl)ethanoate in yield of 94%.The optimum condition was as follows: the molar ratio of methyl 2-(3,4-dimethoxyphenyl)ethanoate and NBS was 1︰ 1,methanol was used as solvent,reaction temperature was room temperature,NBS was used as brominating agent instead of corrosive and toxic bromine.This method can be as a general approach of electrophilic aromatic bromination of the aromatic ethers.
Keywords:aromatic ethers  n-bromosuccinimide  bromination
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