| NBS对芳香醚类化合物选择性溴代研究 |
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| 引用本文： | 张月,刘亚军,金辉,王铨,张辉,许永男.NBS对芳香醚类化合物选择性溴代研究[J].辽宁化工,2012,41(10):1006-1007,1011. |
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| 作者姓名： | 张月 刘亚军 金辉 王铨 张辉 许永男 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
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| 摘 要： | 2-(3,4-二甲氧基苯基)乙酸甲酯与N-溴代丁二酰亚胺(NBS)在摩尔比为1∶1,甲醇为溶剂,室温条件下反应,以94％的收率得到选择性好的芳环单溴代产物2-(2-溴-4,5-二甲氧基苯基)乙酸甲酯.其结构经1H NMR、MS谱确证.用温和的NBS作为溴代试剂避免了传统芳环溴代试剂强腐蚀性及强毒性的缺点,可发展为芳香醚类化合物溴代的一般方法.
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| 关 键 词： | 芳香醚 N-溴代丁二酰亚胺(NBS) 溴代 |
Bromination of Aromatic Ethers by Using NBS as Brominating Agent |
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| ZHANG Yue
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LIU Ya-jun
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JIN Hui
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WANG Quan
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ZHANG Hui
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XU Yong-nan.Bromination of Aromatic Ethers by Using NBS as Brominating Agent[J].Liaoning Chemical Industry,2012,41(10):1006-1007,1011. |
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| Authors: | ZHANG Yue LIU Ya-jun JIN Hui WANG Quan ZHANG Hui XU Yong-nan |
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| Affiliation: | (Shenyang Pharmaceutical University,Liaoning Shenyang 110016,China) |
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| Abstract: | Methyl 2-(2-bromo-4,5-dimethoxyphenyl)ethanoate was synthesized form methyl 2-(3,4-dimethoxyphenyl)ethanoate in yield of 94%.The optimum condition was as follows: the molar ratio of methyl 2-(3,4-dimethoxyphenyl)ethanoate and NBS was 1︰ 1,methanol was used as solvent,reaction temperature was room temperature,NBS was used as brominating agent instead of corrosive and toxic bromine.This method can be as a general approach of electrophilic aromatic bromination of the aromatic ethers. |
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| Keywords: | aromatic ethers n-bromosuccinimide bromination |
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