Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan |
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| Authors: | Te-Sheng Chang Shih-Yu Chao Hsiou-Yu Ding |
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| Affiliation: | Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan; E-Mail: shawna771126@hotmail.com. |
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| Abstract: | Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors. |
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| Keywords: | Caesalpinia sappan inhibition melanogenesis sappanone A tyrosinase |
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