Progress of synthesis and application of hydroxylamine (salts)

The industrial routes，such as Raschig synthesis，reduction of nitrous acid，and one-pot synthesis for preparation of hydroxylamine (salts) are reviewed. Furthermore，the new application of hydroxylamine to synthesis of aniline and phenol derivatives，along with traditional uses of hydroxylamine (salts) for the production of cyclohexanone oxime and hydroxylamine-O-sulfonic acid，is also introduced. With increasing demand for hydroxylamine，future trend on hydroxylamine (salts) synthesis is proposed based on the above discussions，i.e. one-pot synthesis of hydroxylamine can be realized efficiently under mild reaction conditions.