遗传变异与非酒精性脂肪肝病的研究进展

非酒精性脂肪肝病是遗传-环境-代谢相关性疾病,是西方国家最常见的慢性肝病,在我国是继病毒性肝炎后第二位常见肝病,常与肥胖、2型糖尿病、血脂紊乱、高血压等代谢综合征(metabolic syndrome, MS)症状并存,近年来其患病率逐年增加,已成为引起慢性肝病及血清氨基酸转移酶水平升高的主要原因之一。近几年非酒精性脂肪肝病与遗传基础的关系越来越受到关注。本文综述了脂肪酸代谢、胰岛素抵抗、氧化应激、细胞因子等与非酒精性脂肪肝病相关的遗传变异的研究进展。

Study on the relationship between genetic variation and nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease is a group of heredity-environment-metabolism stress disease. It is the most common chronic liver disease in the western country and the second common liver disease after viral hepatitis in our country. Nonalcoholic fatty liver disease is considered as a component of metabolism syndrome, which consists of obesity, type II diabetes mellitus, dyslipidemia and hypertension. Nonalcoholic fatty liver disease have been becoming a common cause of chronic liver diseases and transaminase abnormality. Recently, the genetic basis of Nonalcoholic fatty liver disease is attracting more and more attention. The studies between nonalcoholic fatty liver and genetic variations affecting fatty acid metabolism, insulin resistance, oxidative stress and so on were sumnarized.