| 基因多态性对氟伐他汀药代动力学和药效学特征的影响 |
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| 引用本文： | 刘婧,熊玉卿.基因多态性对氟伐他汀药代动力学和药效学特征的影响[J].金属学报,2012,17(11):1282-1288. |
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| 作者姓名： | 刘婧 熊玉卿 |
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| 作者单位： | 南昌大学医学院临床药理研究所,南昌 330006,江西 |
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| 基金项目： | 国家十一五科技重大专项“建立新药研发安全监测信息化技术平台”子课题“构建I期临床试验研究和风险监测信息化临床技术平台”(2009ZX09309-003-027) |
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| 摘 要： | 氟伐他汀是第一个全化学合成的降胆固醇药物,在临床治疗应用中存在较大的个体疗效差异。肌毒性、肝毒性,横纹肌溶解等是氟伐他汀的潜在不良反应。为了降低不良反应的发生率,研究导致氟伐他汀个体差异大的原因具有重大意义。本文综述了CYP450酶、药物转运体(OATP1B1、OATP1B3、OATP2B1、ABCG2) 多态性对氟伐他汀药代动力学特征的影响和药效基因(CETP、ApoE)的多态性对氟伐他汀药效学特征的影响。以期确保临床用药的安全性和有效性,真正实现临床上的个体化给药。
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| 关 键 词： | 氟伐他汀 药代动力学特征 药效学特征 基因多态性 |
| 收稿时间： | 2012-04-11 |
| 修稿时间： | 2012-07-10 |
Influence of related genetic polymorphisms to pharmacokinetics and pharmacodynamics of Fluvastatin |
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| LIU Jing,XIONG Yu-qing.Influence of related genetic polymorphisms to pharmacokinetics and pharmacodynamics of Fluvastatin[J].Acta Metallurgica Sinica,2012,17(11):1282-1288. |
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| Authors: | LIU Jing XIONG Yu-qing |
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| Affiliation: | Clinical Pharmacology Institute of Nanchang University, Nanchang 330006, Jiangxi, China |
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| Abstract: | Fluvastatin is the first all chemical synthesis of cholesterol drugs. In the clinical treatment of the application of existing large differences.Muscle toxicity, liver toxicity,rhabdomyolysis is fluvastatin potential adverse reactions. In order to reduce the incidence of adverse reactions, so the lead to fluvastatin individual differences of the big reason has the great significance. This paper reviewes the CYP450 enzyme, drug transport body (OATP1B1, OATP1B3, OATP2B1, ABCG2) to fluvastatin pharmacokinetics characteristics of the influence and pharmacophore (CETP, ApoE) to fluoride polymorphisms of simvastatin pharmacodynamics characteristics influence. So as to ensure that the safety and efficacy of clinical medicine, and achieved the clinical personalized medicine. |
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| Keywords: | Fluvastatin Pharmacokinetics characteristics Pharmacodynamics characteristics Gene polymorphism |
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