Novel electrohydrodynamic preparation of porous chitosan particles for drug delivery |
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Authors: | Ketan Pancholi Nassim Ahras Eleanor Stride Mohan Edirisinghe |
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Affiliation: | (1) Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK |
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Abstract: | Uniform spherical chitosan particles of size <10 μm in diameter are important in drug delivery applications due to their excellent
biocompability and biodegradability. A high concentration of chitosan in the particles can help to control the release of
drugs and methods for processing high viscosity chitosan solutions are therefore required. In principle, any type of polymer,
whether hydrophobic or hydrophilic, can be electrosprayed to obtain monodisperse particles of diameter <10 μm. In practice,
however, electrospraying of biopolymers having viscosities of >100 mPa s results in particles >10 μm diameter. In this study,
by reducing surface tension of a high viscosity chitosan suspension, it was found that smaller diameter particles could be
prepared. Chitosan solutions were electrosprayed in the stable cone-jet mode to systematically study the relationship between
particle diameter, viscosity and surface tension. Increasing viscosity resulted in larger diameter particles with a broad
size distribution, but decreasing surface tension had the opposite effect. Results show that a chitosan solution having a
viscosity of ~80 mPa s can be used to prepare chitosan particles of diameter ~2.5 μm which on drying reduced to particles
of 500 nm. |
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