The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones |
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| Authors: | TM Willson JE Cobb DJ Cowan RW Wiethe ID Correa SR Prakash KD Beck LB Moore SA Kliewer JM Lehmann |
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| Affiliation: | Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, Dijon, France. |
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| Abstract: | A new steroidal saponin, aferoside A, has been isolated from the roots of Costus afer. Its structure was established as 3-O-([beta-D-apiofuranosyl-(1-->2)]-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranosyl)-25(R)-spirost-5-en-3 beta-ol by chemical transformations and various spectroscopic methods, mainly 2D NMR techniques (COSY, HMQC and HMBC). |
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