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| 3-氯哒嗪的合成 | |
| 引用本文： | 洪东风,张海祥,袁景军. 3-氯哒嗪的合成[J]. 应用化工, 2011, 40(3) |
| 作者姓名： | 洪东风 张海祥 袁景军 |
| 作者单位： | 1. 洛阳师范学院,化学化工学院,河南,洛阳,471022 2. 陕西阿俾拔致生物科技有限公司,陕西,西安,710075 3. 西北农林科技大学园艺学院,陕西,杨凌,712100 |
| 基金项目： | 西安市科技创新基金项目 |
| 摘 要： | 以3,6-二氯哒嗪为原料,与10%的氢氧化钠溶液在110℃下反应生成3-羟基-6-氯哒嗪,经钯碳催化脱氯得到3-羟基哒嗪,再与三氯氧磷在80℃下回流,制得目标化合物3-氯哒嗪,总收率54.1%,其结构经1H NMR分析确认。 |
| 关 键 词： | 3-氯哒嗪 合成 收率 |
Synthesis of 3-chloropyridazine |
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| HONG Dong-feng,ZHANG Hai-xiang,YUAN Jing-jun. Synthesis of 3-chloropyridazine[J]. Applied chemical industry, 2011, 40(3) | |
| Authors: | HONG Dong-feng ZHANG Hai-xiang YUAN Jing-jun |
| Affiliation: | HONG Dong-feng1,ZHANG Hai-xiang2,YUAN Jing-jun3 (1.School of Chemistry and Chemical Engineering,Luoyang Normal University,Luoyang 471022,China,2.Shaanxi A-big-bridge Biology Sci-tech Co.,Ltd.,Xi'an 710075,3.College of Horticulture,Northwest Agricultural & Forestry University,Yangling 712100,China) |
| Abstract: | The 3-hydroxy-6-chloropyridazine was prepared using 3,6-dichloropyridazine as starting material with sodium hydroxide at 110 ℃.The 3-hydroxypyridazine was synthesized via palladium on activated carbon dechlorination.Reaction of 3-hydroxypyridazine with phosphorus oxychloride at 80 ℃ gave the target compound 3-chloropyridazine,and the total yield was 54.1%.Its structure was confirmed by 1H NMR analysis. |
| Keywords: | 3-chloropyridazine synthesis yield |
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