A comparative study of the physical and mechanical properties of three natural corals based on the criteria for bone–tissue engineering scaffolds |
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Authors: | Yu-Chun Wu Tzer-Min Lee Kuo-Hsun Chiu Shyh-Yu Shaw Chyun-Yu Yang |
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Affiliation: | (1) Institute of Biotechnology, National Cheng Kung University, Tainan, 70428, Taiwan;(2) Institute of Oral Medicine, National Cheng Kung University Medical College, Tainan, 70428, Taiwan;(3) Institue of Marine Biology, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan;(4) Department of Chemistry, National Cheng Kung University, Tainan, 70428, Taiwan;(5) Department of Orthopedics, National Cheng Kung University Medical College, Tainan, 70428, Taiwan |
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Abstract: | Coral has been used for bone grafts since 1970. Because coral has the advantages of good osteoconduction, biocompatibility,
and biodegradation, it is also suitable for scaffolds used in bone–tissue engineering. However, the skeletons of different
species of corals often vary significantly, and very few studies focus on the assessment of the permeability and mechanical
properties of coral structure. In order to better understand the use of coral in bone tissue–engineering, we selected three
typical models (Acropora sp., Goniopora sp., and Porites sp.) to analyze for pore size, porosity, permeability, and mechanical strength. We found Goniopora and Porites had homogenous structure and Acropora had oriented pores and irregular pore size. Acropora had the largest permeability, however, the transverse section was closed and the useful size was limited because of its habitat
type. Porites had the smallest pore size and had the lowest permeability. Our data indicated that Goniopora sp. can be considered as the most promising source of scaffolds for bone–tissue engineering because of its high porosity
(73%) and that its permeability and mechanics were similar to those in human cancellous bone. In conclusion, we analyzed the
impact of the macroporous structure of coral on the permeability and mechanical properties that provide indicators for designing
the optimal scaffold for bone–tissue engineering. |
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