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| 紫杉醇长循环脂质体的制备及其药动学研究 | |
| 引用本文： | 张子豫,贾丽君,龚建刚,李广宙,康白.紫杉醇长循环脂质体的制备及其药动学研究[J].食品与药品,2009,11(1). |
| 作者姓名： | 张子豫 贾丽君 龚建刚 李广宙 康白 |
| 作者单位： | 1. 潍坊医学院药理学教研室,山东,潍坊,261042 2. 首都医科大学附属北京同仁医院,北京,100730 3. 河北农业大学中兽医学院,河北,定州073000 4. 潍坊医学院附属医院核医学科,山东,潍坊,261042 |
| 摘 要： | 目的制备紫杉醇长循环脂质体并观察其在大鼠体内的药动学.方法用薄膜分散法制备紫杉醇长循环脂质体;HPLC法测定血浆中紫杉醇的药物浓度;用3P97程序计算药动学参数.结果脂质体粒径为(106.5±1.7)nm,包封率为(87.5士2.5)%,紫杉醇长循环脂质体和紫杉醇注射液的血药浓度-时间曲线均符合二室模型,药动参数t1/2β分别为(7.32±1.24)h和(0.32±0.06)h,AUC分别为(23.85±1.20)μg·h·mL-1和(5.08±0.45)μg·h·mL-1.结论与紫杉醇注射液相比,紫杉醇长循环脂质体显著延长了紫杉醇在血液循环系统中的驻留时间,具有长效作用. |
| 关 键 词： | 紫杉醇 长循环脂质体 包封率 药动学 |
Preparation of Long-circulating Paclitaxel-containing Liposomes and Its Pharmacokinetics |
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| ZHANG Zi-yu,JIA Li-jun,GONG Jian-gang,LI Guang-zhou,KANG Bai.Preparation of Long-circulating Paclitaxel-containing Liposomes and Its Pharmacokinetics[J].Food and Drug,2009,11(1). | |
| Authors: | ZHANG Zi-yu JIA Li-jun GONG Jian-gang LI Guang-zhou KANG Bai |
| Affiliation: | 1.Department of Pharmacology;Weifang Medical University;Weifang 261042;China;2.Beijing Tongren Hospital affiliated to Capital Medical University;Beijing 100730;3.College Of Traditional Chinese Veterinary Medicine;Hebei Agricultural University;Dingzhou 073000;4.Department of Nuclear Medicine;Affiliated Hospital of Weifang Medical University;China |
| Abstract: | |
| Keywords: | paclitaxel long-circulating liposome entrapment efficiency pharmacokinetics |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |