| 柠檬酸催化合成阿司匹林 |
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| 引用本文： | 隆金桥,凌绍明. 柠檬酸催化合成阿司匹林[J]. 云南化工, 2008, 35(5) |
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| 作者姓名： | 隆金桥 凌绍明 |
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| 作者单位： | 百色学院,广西,百色,533000 |
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| 摘 要： | 以水杨酸和乙酸酐为原料,柠檬酸为催化剂合成阿司匹林,探讨了酸酐物质的量比、催化剂用量和反应时间、反应温度对产品收率的影响。研究结果表明,当酸酐物质的量比为1∶3,柠檬酸用量为1.0 g,反应时间为40 min,反应温度为70℃,纯化后阿司匹林收率达91.0%。
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| 关 键 词： | 阿司匹林 催化合成 柠檬酸 |
Catalytic Synthesis of Aspirin by Citric Acid |
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| LONG Jin-Qiao,LING Shao-ming. Catalytic Synthesis of Aspirin by Citric Acid[J]. Yunnan Chemical Technology, 2008, 35(5) |
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| Authors: | LONG Jin-Qiao LING Shao-ming |
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| Abstract: | Aspirin was synthesized from salicylic acid and acetyl anhydride catalyzed by citric acid,and effect of ratio of acid to anhydride,catalyst dose and reaction time on the yield of product was investigated.Result showed the yield of purified aspirin was 91.0% when the ratio of acid to anhydride was 1:3,citric acid dose was 1.0 g,and reacted at 70 ℃ for 40 min. |
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| Keywords: | aspirin catalytic synthesis citric acid |
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