Plasma Omega-3 Fatty Acid Response to a Fish Oil Supplement in the Healthy Elderly |
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Authors: | Milène Vandal Erika Freemantle Jennifer Tremblay-Mercier Mélanie Plourde Mélanie Fortier Joannie Bruneau Johannie Gagnon Michel Bégin Stephen C. Cunnane |
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Affiliation: | (1) Research Center on Aging, Health and Social Sciences Center, Sherbrooke University Geriatrics Institute, 1036 Belvédère St. South, Sherbrooke, QC, J1H 4C4, Canada;(2) Departments of Medicine and Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, QC, Canada |
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Abstract: | Little information is available concerning whether incorporation of dietary omega-3 fatty acids into plasma lipids changes during healthy aging. Elderly (74 ± 4 years old) and young (24 ± 2 years old) adults were given a fish oil supplement for 3 weeks that provided 680 mg/day of docosahexaenoic acid and 320 mg/day of eicosapentaenoic acid, followed by a 2 week wash-out period. Compliance was monitored by spiking the capsules with carbon-13 glucose, the excretion of which was measured in breath CO2. In response to the supplement, plasma docosahexaenoic acid rose 42% more in the elderly but eicosapentaenoic responded similarly in both groups. Despite raising docosahexaenoic acid intake by five to tenfold, the supplement did not raise plasma free docosahexaenoic acid (% or mg/dL) in either group. We conclude that healthy aging is accompanied by subtle but significant changes in DHA incorporation into plasma lipids. |
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Keywords: | Fish oil Compliance Omega-3 fatty acids ω 3 Polyunsaturated fatty acids Elderly Arachidonic acid Docosahexaenoic acid Eicosapentaenoic acid |
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