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Block bootstrap methods for the estimation of the intensity of a spatial point process with confidence bounds
Authors:T MATTFELDT  H HÄBEL  F FLEISCHER
Affiliation:1. Institute of Pathology, University of Ulm, , Ulm, Germany;2. Faculty of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, , Gothenburg, Sweden;3. Medical Data Services/Biostatistics, Boehringer‐Ingelheim Pharma GmbH & Co. KG, , Ingelheim, Germany
Abstract:This paper deals with the estimation of the intensity of a planar point process on the basis of a single point pattern, observed in a rectangular window. If the model assumptions of stationarity and isotropy hold, the method of block bootstrapping can be used to estimate the intensity of the process with confidence bounds. The results of two variants of block bootstrapping are compared with a parametric approximation based on the assumption of a Gaussian distribution of the numbers of points in deterministic subwindows of the original pattern. The studies were performed on patterns obtained by simulation of well‐known point process models (Poisson process, two Matérn cluster processes, Matérn hardcore process, Strauss hardcore process). They were also performed on real histopathological data (point patterns of capillary profiles of 12 cases of prostatic cancer). The methods are presented as worked examples on two cases, where we illustrate their use as a check on stationarity (homogeneity) of a point process with respect to different fields of vision. The paper concludes with various methodological discussions and suggests possible extensions of the block bootstrap approach to other fields of spatial statistics.
Keywords:Bootstrap  computer‐intensive methods  dependent data  intensity  pathology  point process  resampling  simulation  spatial statistics  stereology  stochastic geometry
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