| N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺的合成 |
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| 引用本文： | 陆佳蕾,苏烨,姜俐,朱冬春,董彦彬,金东元.N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺的合成[J].化学世界,2009,50(2). |
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| 作者姓名： | 陆佳蕾 苏烨 姜俐 朱冬春 董彦彬 金东元 |
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| 作者单位： | 上海应用技术学院化学工程系,上海,200235;上海应用技术学院化学工程系,上海,200235;上海应用技术学院化学工程系,上海,200235;上海应用技术学院化学工程系,上海,200235;上海应用技术学院化学工程系,上海,200235;上海应用技术学院化学工程系,上海,200235 |
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| 基金项目： | 上海市大学生科技创新基金 |
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| 摘 要： | 以氯乙酸甲酯、4-苯氧基苯酚为原料,在无水碳酸钾存在下,N,N-二甲基甲酰胺(DMF)为溶剂,制备了中间体2-(4-苯氧基苯氧基)乙酸甲酯(Ⅰ),进而,中间体(Ⅰ)和二甲胺反应。得到目的产物N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅱ)。考察了反应温度、反应时间、物料投料比对目的产物(Ⅱ)收率的影响,从而确定了合成工艺条件为:反应温度15~20°C;反应时间3.5~4 h;物料投料比n(Ⅰ)∶n(二甲胺)=1.0∶1.4。在此条件下,N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺的收率达80%以上。化合物的结构经IR1、H NMR和元素分析进行了表征。
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| 关 键 词： | 氯乙酸甲酯 4-苯氧基苯酚 N’N-二甲基-2-(4-苯氧基苯氧基)乙酰胺 二甲胺 |
Synthesis of N,N-Dimethyl-2-(4-phenoxy phenoxy) acetamide |
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| LU Jia-lei,SU Ye,JIANG Li,ZHU Dong-chun,DONG Yan-bin,JIN Dong-yuan.Synthesis of N,N-Dimethyl-2-(4-phenoxy phenoxy) acetamide[J].Chemical World,2009,50(2). |
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| Authors: | LU Jia-lei SU Ye JIANG Li ZHU Dong-chun DONG Yan-bin JIN Dong-yuan |
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| Affiliation: | Department of Chemical Engineering;Shanghai Institute of Technology;Shanghai 200235;China |
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| Abstract: | Treatment of methyl chloroacetate with 4-phenoxyphenol in DMF solvent in the presence of anhydrous K_2CO_3 gave methyl 2-(4-phenoxy phenoxy) acetate intermediate(I),which reacted with dimethylamine to give N,N-dimethyl-2-(4-phenoxy phenoxy) acetamide.The effects of reaction conditions such as reaction temperature,reaction time and the molar ratio of materials on reaction yield were studied.The optimum conditions were determined as follows: reaction temperature was 15~20°C,reaction time was 3.5~4 h and the molar ratio of I to dimethylamine was 1.0∶1.4. The yield reached 80%.The prepared compound was identified by IR,()~1H NMR and elemental analysis. |
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| Keywords: | methyl chloroacetate 4-phenoxyphenol N N-dimethyl-2-(4-phenoxy phenoxy) acetamide dimethylamine |
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