Effects of oleic,arachidonic and 5,8,11,14-nonadecatetraenoic acids on lipid secretion and ketogenesis in perfused rat liver |
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| Authors: | Ikuo Ikeda Jun Murakami Takayuki Oka Michihiro Sugano Hideaki Yamada Sakayu Shimizu Hiroshi Kawashima Yoshifumi Shinmen Teruo Amachi |
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| Affiliation: | (1) Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Sakyo-ku, 606 Kyoto;(2) Laboratory of Microbial Science, Institute for Fundamental Research, Suntory Ltd., Shimamoto, 618 Osaka, Japan;(3) Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812 Fukuoka, Japan |
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| Abstract: | The effects of perfused oleic (18∶1n−9), arachidonic (20∶4n−6) and 5,8,11,14-nonadecatetraenoic (19∶4n−5) acids on triglyceride
and cholesterol secretion and ketone body production were studied in isolated rat liver. As compared to oleic and 19∶4n−5
acids, both ketone body production and triglyceride secretion were significantly lowered when arachidonic acid was perfused.
The concentration of triglyceride in the post-perfused liver was lower upon perfusion with arachidonic acid than upon perfusion
with oleic acid or 19∶4n−5 acid. Cholesterol secretion in the liver perfused with arachidonic acid or 19∶4n−5 acid was significantly
higher than with oleic acid. The concentration of cholesterol in the post-perfused liver was slightly but significantly higher
with 19∶4n−5 acid than with the other fatty acids. The results suggest that 19∶4n−5 acid when compared with arachidonic acid
affects lipid metabolism in liver differently. |
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