Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells |
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| Authors: | E Hanon G Meyer A Vanderplasschen C Dessy-Doizé E Thiry PP Pastoret |
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| Affiliation: | Departments of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liège, B-4000 Liège, Belgium. hanon@stat.fmv.ulg.ac.be |
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| Abstract: | Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although penetration of BHV-1 is not required, attachment of BHV-1 viral particles is essential for the induction of apoptosis. |
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