| 1-氯-2-甲基-4-乙酰氧基-2-丁烯制备方法的改进 |
| |
| 引用本文： | 胡四平,王伟,孙雄生,俞春晓,邓红霞. 1-氯-2-甲基-4-乙酰氧基-2-丁烯制备方法的改进[J]. 浙江化工, 2007, 38(7): 5-6 |
| |
| 作者姓名： | 胡四平 王伟 孙雄生 俞春晓 邓红霞 |
| |
| 作者单位： | 1. 浙江医药股份有限公司维生素厂,浙江,绍兴,312000
2. 浙江省化工研究院,浙江,杭州,310023 |
| |
| 摘 要： | 用次氯酸钙和乙酸作用生成的缓冲体系非常温和,在此体系下以异戊二烯为原料进行的氯醇化反应收率可达88.6%,反应混合物可以进一步酯化重排制备维生素A的中间体1-氯-2-甲基-4-乙酰氧基-2-丁烯。
|
| 关 键 词： | VA乙酸酯 1-氯-2-甲基-4-乙酰氧基-2-丁烯 次氯酸钙 氯醇化反应 |
| 文章编号： | 1006-4184（2007）07-0005-02 |
| 修稿时间： | 2007-03-26 |
Improved Method for the Synthesis of 1-Chloro-2-methyl-4-(acetyloxy)-2-butene |
| |
| HU Si-ping,WANG Wei,SUN Xiong-sheng,YU Chun-xiao,DENG Hong-xia. Improved Method for the Synthesis of 1-Chloro-2-methyl-4-(acetyloxy)-2-butene[J]. Zhejiang Chemical Industry, 2007, 38(7): 5-6 |
| |
| Authors: | HU Si-ping WANG Wei SUN Xiong-sheng YU Chun-xiao DENG Hong-xia |
| |
| Affiliation: | 1,Zhejiang Medicine Co.Ltd., Xinchang Pharmaceutical Factory, Xinchang 312500,China; 2,The Chemical Industry of Zheng jiang 310023, China |
| |
| Abstract: | The buffer system made of calcium hypochlorite and acetic acid is very soft,which is suitable for chlorohydrin reaction of isoprene.The yield is improved to 88.6%.The reaction mixture then undergo esterification and rearrangement reaction to prepare 1-chloro-2-methyl-4-(acetyloxy)-2-butene,which is a important intermediate of vitamin A. |
| |
| Keywords: | Retinol acetate 1-chloro-2-methyl-4-(acetyloxy)-2-butene Calcium hypochlorite Chlorohydrin reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
