Turning down the heat: new routes to inhibition of inflammatory signaling by prostaglandin H2 synthases |
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Authors: | DG Munroe CY Lau |
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Affiliation: | R.W. Johnson Pharmaceutical Research Institute, Don Mills, Ontario, Canada. |
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Abstract: | Many nonsteroidal anti-inflammatory drugs act by inhibiting the cyclooxygenase activity of prostaglandin H2 synthase (PGHS), a key enzyme in the biosynthesis of prostaglandins. Gastric toxicity remains a serious problem with the current drugs, however. Recent advances in the understanding of PGHS now suggest two possible approaches to producing drugs with fewer side effects. |
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