| Amberlyst15催化7-羟基-4-甲基香豆素的无溶剂合成 |
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| 引用本文： | 韩雪,辛秀兰,金琼花.Amberlyst15催化7-羟基-4-甲基香豆素的无溶剂合成[J].广州化工,2009,37(4):72-73,97. |
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| 作者姓名： | 韩雪 辛秀兰 金琼花 |
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| 作者单位： | 1. 首都师范大学化学系,北京,100048
2. 北京工商大学化工学院,北京,100048 |
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| 摘 要： | 研究了在无溶剂条件下，Amberlyst15催化间苯二酚和乙酰乙酸乙酯合成7-羟基-4-甲基香豆素，较系统地考察了反应温度、反应时间、催化剂用量、原料配比对反应产率的影响，得到最优反应条件：反应时间160min，反应温度110℃，催化剂用量0．5g，间苯二酚与乙酰乙酸乙酯的物质的量比为1：1。上述条件下，7-羟基-4-甲基香豆素的产率达到65．16％。
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| 关 键 词： | Amberlyst 15 7-羟基-4-甲基香豆素 无溶剂合成 |
Synthesis of 7-hydroxy-4-methyl Coumarin Catalyzed by Amberlyst 15 without Solvent |
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| HAN Xue,XIN Xiu-lan,JIN Qiong-hua.Synthesis of 7-hydroxy-4-methyl Coumarin Catalyzed by Amberlyst 15 without Solvent[J].GuangZhou Chemical Industry and Technology,2009,37(4):72-73,97. |
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| Authors: | HAN Xue XIN Xiu-lan JIN Qiong-hua |
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| Affiliation: | 1 Department of Chemistry;Capital Normal University;Beijing100048;2 College of Chemistry Engineering;Beijing Technology and Business University;Beijing 100048;China |
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| Abstract: | 7-hydroxy-4-methyl coumarin was synthesized with resorcinol and ethylace toacetate as raw materials without solvent in the presence of amberlyst 15. Effects of reaction temperature, reaction time, catalyst dosage, and mole ratio of resoreinol to ethylace toacetate on yield were investigated. The optimum conditions were as follows： reaction time 160min, reaction temperature 110℃, catalyst dosage 0.5g, and mole ratio of resoreinol to ethyl ethylace toaeetate 1：1. Under the conditions, the yield to 7-hydroxy-4-methyl eoumarin was 65.16%. |
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| Keywords: | Amberlyst 15 |
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