An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases |
| |
Authors: | Bidur Bhandary Anu Marahatta Hyung-Ryong Kim Han-Jung Chae |
| |
Affiliation: | 1.Department of Pharmacology, School of Medicine, Chonbuk National Univeristy, Jeonju 561-180, South Korea; E-Mails: (B.B.); (A.M.);2.Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan 570-749, South Korea |
| |
Abstract: | The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress. |
| |
Keywords: | ER stress ER stress associated disease ER associated oxidative stress disulfide bond formation PDI ERO-1α mitochondria electron transport chain |
|
|