不同钙补充剂对缺铁性贫血大鼠钙、铁吸收的影响

探讨柠檬酸苹果酸钙(Calcium citrate malate,CCM)、碳酸钙(Calcium carbonate,Ca CO3)、骨钙(Bone calcium,BC)三种常用钙剂与富马酸亚铁(Ferrous fumarate,FF)合用对钙、铁吸收的影响,以及三种钙剂的生物利用度,为消费者选择合适的钙剂提供实验依据。建立大鼠缺铁性贫血模型,通过检测大鼠血红蛋白(Hemoglobin,Hb)和血清铁(Serum iron concentration,SFe)含量,观察三种钙源与铁制剂合用对钙、铁吸收的影响;通过药代动力学考察血清降钙素(Calcitonin,CT)含量,评估三种钙剂的生物利用度。实验结果表明CCM/FF组与Ca CO3/FF组和BC/FF组相比,CCM/FF组合给药3 d后即能显著升高缺铁性贫血大鼠血红蛋白含量,其血红蛋白含量给药14 d极显著高于Ca CO3/FF组(p<0.01);CCM/FF组的血清铁含量在给药1 d后即显著高于Ca CO3/FF组(p<0.01),说明CCM对铁吸收的抑制作用较小。此外,CCM的降钙素曲线下面积(Area under the curve,AUC)高于Ca CO3及BC,间接反映了CCM吸收率较其它钙剂多。 

Effect of different calcium supplements on the absorption of calcium and ferrum in the iron deficiency anemia rats

The effect of calcium citrate malate( CCM),calcium carbonate( Ca CO3),and bone calcium( BC) added ferrous fumarate( FF) on the absorption of ferrum,calcium were investigated,respectively.By iron deficiency animal model,the concentrations of serum ferrum( SFe) and hemoglobin( Hb) were determined as well as the pharmacokinetic curve of calcitonin( CT) for the three groups in rats.The results showed that the concentrations of Hb were increased significantly by CCM / FF treatments only after 3 days.Furthermore,the concentrations of Hb and SFe by CCM / FF treatments were significantly higher than those by Ca CO3/ FF treatments after 14 days and 1 day,respectively( p < 0.01). These results indicated that CCM had less inhibition on Fe absorption compared with Ca CO3.In addition,compared with Ca CO3 and BC treatments,the CCM treatment had the highest AUC of the calcitonin,which implied that CCM was better in bioavailability than Ca CO3 and BC.