| Preclinical evaluation on ~(125)I-BMIPP |
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| 作者姓名： | LU Chun-Xiong WU Chun-Ying JI Shu-Ren DING Shi-Yu CHENG Zheng-Ping |
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| 作者单位： | State Key Laboratory of Nuclear Medicine，Jiangsu Institute of Nuclear Medicine，Wuxi 214063 |
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| 基金项目： | Natural Science Foundation of Jiangsu Province(No.97185)，by Department of Health of Jiangsu Province(No.H9508) |
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| 摘 要： | The biodistribution of 125I-BMIPP and the variation of myocardial uptake of 125I-BMIPP using the metabolic intervention drug were reported. Myocardial uptake of the 125I-BMIPP in rats showed a peak of 5.70ID%/g at 2 min. The ratios of myocardium to blood, to liver and to lung at 30 min were 3.40, 2.64 and 2.88 respectively. The initial elimination half time of 4.0 min in rabbits was in accordance with the half elimination time of free fatty acid from blood. Myocardial uptake of 125I-BMIPP in the group of glucose-insulin was significantly increased (p<0.05) than those of the normal control. In vivo and in vitro binding test for 125I-BMIPP to HSA showed a rather constant level of activation up to 2 h. Partition coefficients (1gP) were 1.93 and 1.68, respectively.
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| 关 键 词： | (125)~I labeled β-methyl-ω-p-iodophenyl pentadenoic acid (BMIPP) Fatty acid Biodistribution Metabolic intervention |
Preclinical evaluation on 125 I-BMIPP |
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| LU Chun-Xiong,WU Chun-Ying,JI Shu-Ren,DING Shi-Yu,CHENG Zheng-Ping.Preclinical evaluation on ~(125)I-BMIPP[J].Nuclear Science and Techniques,2003,14(4). |
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| Authors: | LU Chun-Xiong WU Chun-Ying JI Shu-Ren DING Shi-Yu CHENG Zheng-Ping |
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| Abstract: | The biodistribution of 125I-BMIPP and the variation of myocardial uptake of 125I-BMIPP using the metabolic intervention drug were reported. Myocardial uptake of the 125I-BMIPP in rats showed a peak of 5.70ID%/g at 2 min. The ratios of myocardium to blood, to liver and to lung at 30 min were 3.40, 2.64 and 2.88 respectively. The initial elimination half time of 4.0 min in rabbits was in accordance with the half elimination time of free fatty acid from blood. Myocardial uptake of 125I-BMIPP in the group of glucose-insulin was significantly increased (p<0.05) than those of the normal control. In vivo and in vitro binding test for 125I-BMIPP to HSA showed a rather constant level of activation up to 2 h. Partition coefficients (1gP) were 1.93 and 1.68, respectively. |
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| Keywords: | Fatty acid Biodistribution Meta-bolic intervention |
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