Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells |
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| Authors: | Anna Matiushkina Ilia Litvinov Anastasia Bazhenova Tatiana Belyaeva Aliaksei Dubavik Andrei Veniaminov Vladimir Maslov Elena Kornilova Anna Orlova |
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| Affiliation: | 1.Faculty of Photonics, School of Physics and Engineering, ITMO University, 197101 Saint Petersburg, Russia; (A.M.); (A.B.); (A.D.); (A.V.); (V.M.); (A.O.);2.Institute of Cytology, Russian Academy of Science, 194064 Saint Petersburg, Russia; (T.B.); (E.K.);3.Higher School of Biomedical Systems and Technologies, Peter the Great St. Petersburg Polytechnic University, 195251 Saint Petersburg, Russia |
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| Abstract: | Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite’s stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status. |
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| Keywords: | quantum dots SPIONs magnetic-luminescent composites photoluminescence theranostics |
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