Comparative effect of glucagon,dibutyryl cyclic AMP,and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes |
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| Authors: | Irma N T de Gómez Dumm María J T de Alaniz Rofolfo R Brenner |
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| Affiliation: | (1) Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, calle 60y 120, 1900 La Plata, Argentina;(2) Present address: Carrera del Investigador Científico of the Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina |
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| Abstract: | The effect of glucagon, dibutyryl cyclic adenosine 3′,5′-monophosphate, and epinephrine on the biosynthesis of polyunsaturated
fatty acids of the linoleic acid family was studied. The incubations were performed with rat liver microsomes and labeled
linoleic acid under desaturating and elongating conditions. Under desaturating conditions, linoleic acid was converted to
γ-linolenic acid, whereas under elongating conditions it was converted to 20∶2ω6. Glucagon, dibutyryl cyclic AMP, and epinephrine
decreased the oxidative desaturation of linoleic acid to γ-linolenic acid while the elongating reaction was not modified in
the experimental conditions tested. Consequently, the results support the hypothesis that the oxidative desaturation of linoleic
acid to γ-linolenic acid is the main controllable step in the biosynthesis of polyunsaturated fatty acids of the linoleic
acid family in the microsomes. |
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