银/壳聚糖-g-甲基丙烯酸甲酯复合物的制备与抗菌性能

采用液相化学还原法合成了Ag/壳聚糖(CS)复合胶乳, 并制备了 Ag/CS-g-甲基丙烯酸甲酯(MMA)复合物。研究结果表明, 纳米Ag粒子对CS与MMA的接枝聚合起阻碍作用, 导致接枝率和接枝效率比无Ag粒子存在时有所下降。结构表征显示纳米Ag粒子均匀分散于复合物中。抗菌评价结果表明: Ag/CS和 Ag/CS-g-MMA 复合抗菌剂具有比Ag或CS单一抗菌剂更高效的抗菌性能, Ag/CS-g-MMA 复合物对E.coli、 B.subtilis、 S.aureus和P.aeruginosa四种菌的抑菌率分别为96.3%、 97.6%、 93.2%、 95.8%; Ag/CS-g-MMA复合抗菌剂的抗菌性能是纳米Ag粒子与CS协同作用的结果。 

Preparation and characterization of Ag/chitosan-g-methylmethacrylate composite nanoparticles

Ag/chitosan (CS) composite colloids were synthesized by the liquid-phase chemical reduction and then Ag/CS-g-methylmethacrylate (MMA) composite was prepared by graft polymerization.The results show that Ag nanoparticles hinder the graft polymerization of CS with MMA, which results in the decrease of the graft percentage and graft efficiency in comparison with those without Ag nanoparticles.The structural characterizations verify that Ag nanoparticles disperse uniformly in the composites.The evaluations of antimicrobial activities show that the antibacterial performances of Ag/CS and Ag/CS-g-MMA composites are higher than that of Ag or CS alone.Among them, the inhibition rate of Ag/CS-g-MMA to four kinds of bacteria of E.coli, B.subtilis, S.aureus and P.aeruginosa are 96.3%、 97.6%、 93.2%、 95.8%, respectively.The antibacterial mechanisms of Ag nanoparticles and CS were studied.The antibacterial activities of Ag/CS based antimicrobial are displayed by the cooperation of Ag nanoparticles with CS.