| 基于金纳米棒的DNA杂交检测 |
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| 引用本文： | 陈强,李凯,周宇荀,王文静,肖君华. 基于金纳米棒的DNA杂交检测[J]. 传感器与微系统, 2011, 30(10): 137-140 |
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| 作者姓名： | 陈强 李凯 周宇荀 王文静 肖君华 |
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| 作者单位： | 1. 东华大学生物科学与技术研究所,上海,201620
2. 上海疾病预防控制中心,上海,200336 |
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| 基金项目： | 卫生部科技重大专项“十一五”计划资助项目(2008ZX10004—002); 教育部中央高校基本科研业务费专项资金资助项目(10D10515); 上海市科委科技攻关计划资助项目(09391911500) |
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| 摘 要： | 金纳米棒具有独特的光学性质与良好的生物适应性,在生物医学领域得到了日益广泛的应用.利用种子生长法,通过改变表面活性剂十二烷基二甲基苄基氯化铵(BDAC)的浓度所制备的8种不同长径比(AR)的金纳米棒,具有不同位置的纵向表面等离子共振(SPR)峰.在金纳米棒和非标记探针DNA的混合盐溶液中加入靶标DNA后检测,发现金纳米...
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| 关 键 词： | 金纳米棒 分子检测 表面等离子共振 吸光度 |
Detection of DNA hybridization based on gold nanorod |
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| CHEN Qiang,LI Kai,ZHOU Yu-xun,WANG Wen-jing,XIAO Jun-hua. Detection of DNA hybridization based on gold nanorod[J]. Transducer and Microsystem Technology, 2011, 30(10): 137-140 |
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| Authors: | CHEN Qiang LI Kai ZHOU Yu-xun WANG Wen-jing XIAO Jun-hua |
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| Affiliation: | CHEN Qiang1,LI Kai1,ZHOU Yu-xun1,WANG Wen-jing2,XIAO Jun-hua1(1.Institute of Biological Sciences and Biotechnology,Donghua University,Shanghai 201620,China,2.Shanghai Centers for Disease Control and Prevention,Shanghai 200336,China) |
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| Abstract: | Gold Nanorods have been widely used in biomedical field,due to their unique optical properties and excellent biocompatibilities.Eight different aspect ratios(AR)gold nanorods which own different longitudinal surface plasmon resonance modes is described.Gold nanorods are prepared with the seed-mediated growth method with various concentration of benzyldimethylhexadecylammonium chloride(BDAC).While target DNA is added to the mixed buffer of nonmodified gold nanorods and label-free probe DNA with high ionic st... |
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| Keywords: | gold nanorod(GNR) molecular detection surface plasmon resonance(SPR) absorbance |
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