| 甲状腺球蛋白测定的临床意义及影响因素 |
| |
| 引用本文： | 戴庆靖,匡安仁.甲状腺球蛋白测定的临床意义及影响因素[J].同位素,2007,20(2):120-125. |
| |
| 作者姓名： | 戴庆靖 匡安仁 |
| |
| 作者单位： | 四川大学华西医院核医学科 四川成都610041 |
| |
| 摘 要： | 甲状腺球蛋白(Tg)是分化型甲状腺癌(DTC)的肿瘤标志物。定期随访血清Tg有助于对DTC复发和转移的诊断、病人预后的评价和监测治疗效果。目前临床上常用放射免疫分析法(RIA)和非放射性的免疫量度分析法(IMA)测量血清Tg。但这些方法存在较多技术问题,使其临床应用受到了限制,主要有:方法间的变异较大、灵敏度不够高、批内精确度不够好、高浓度Tg的钩变效应(hook effect)、甲状腺球蛋白抗体(TgAb)的干扰等。其中TgAb的干扰是临床上最常见的问题。
|
| 关 键 词： | 放射免疫分析法 甲状腺球蛋白 分化型甲状腺癌 甲状腺球蛋白抗体 免疫量度分析法 |
| 文章编号： | 1000-7512（2007）02-0120-05 |
| 收稿时间： | 2005-01-26 |
| 修稿时间： | 2005-01-262005-04-07 |
The Clinical Application and Interference Factors of Serum Thyroglobulin Measurement |
| |
| DAI Qing-jing,KUANG An-ren.The Clinical Application and Interference Factors of Serum Thyroglobulin Measurement[J].Isotopes,2007,20(2):120-125. |
| |
| Authors: | DAI Qing-jing KUANG An-ren |
| |
| Affiliation: | Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China |
| |
| Abstract: | Serum thyroglobulin(Tg) is primarily used as a tumor marker to detect recurrent or metastasis disease in patients with differentiated thyroid carcinomas.Currently,radioimmunoassay(RIA) or immunometric assay(IMA) is used to measure serum Tg concentration in most clinical laboratories.There are several technical limitations of serum Tg measurement,which includes wide between-method variability,inadequate sensitivity,suboptimal between-run precision,hook effect,and Tg autoantibody(TgAb) interference(which results in falsely low or undetectable IMA values and high RIA values in TgAb-positive patients with disease). |
| |
| Keywords: | radioimmunoassay(RIA) thyroglobulin(Tg) differentiated thyroid carcinomas(DTC) thyroglobulin autoantibody(TgAb) immunometric assay(IMA) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《同位素》浏览原始摘要信息 |
|
点击此处可从《同位素》下载全文 |
