| 4-(2′,4′-二氟苯基)苯乙酮的合成研究 |
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| 引用本文： | 周卫红,楼其向,许文松. 4-(2′,4′-二氟苯基)苯乙酮的合成研究[J]. 精细石油化工, 2004, 4(4): 21-24 |
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| 作者姓名： | 周卫红 楼其向 许文松 |
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| 作者单位： | 浙江大学材料与化工学院,杭州,310027 |
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| 摘 要： | 以2’,4’-二氟联苯为原料,以乙酰氯为酰化剂,二氯甲烷为溶剂,经Friedel-Crafts酰化反应制备了4-(2’,4’-二氟苯基)苯乙酮,确定的最佳反应条件为:乙酰氯的添加温度低于15℃,反应温度25℃,二氟联苯/乙酰氯/三氯化铝(摩尔比)为1:1.22:1.34,反应时间为3 h,并对后处理过程进行了改进,4-(2’,4’-二氟苯基)苯乙酮的最佳收率达到96.3％(基于二氟联苯),熔点70～72℃,纯度98.5％。
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| 关 键 词： | 2’,4’-二氟联苯 4-(2’,4’-二氟苯基)苯乙酮 Friedel-Crafts反应 |
| 修稿时间： | 2004-01-22 |
STUDY ON SYNTHESIS OF 4- (2'''', 4''''-DIFLUOROPHENYL) ACETOPHENONE |
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| Zhou Weihong,Lou Qixiang and Xu Wensong. STUDY ON SYNTHESIS OF 4- (2'''', 4''''-DIFLUOROPHENYL) ACETOPHENONE[J]. Speciality Petrochemicals, 2004, 4(4): 21-24 |
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| Authors: | Zhou Weihong Lou Qixiang Xu Wensong |
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| Abstract: | Using acetyl chloride as acetylating agent and dichloromethane as solvent, the 4-(2',4'-difluorophenyl) acetophenone was synthesized from 2', 4'-difluorobiphenyl via Friedel-Crafts reaction. The optimal synthetic conditions were obtained as follows: n(2',4'-difluorobiphenyl): n(acetyl chloride): n(AlCl_3)=1:1.22:1.34, addition temperature of ace tyl chloride<15℃, reaction temperature 25℃, reaction time 3h, and the after treatment of the product was improved also. The molar yield of product is over 96%(based on 2',4'-difluorobiphenyl), m.p. 70-72℃, purity 98.5%. |
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| Keywords: | 2' 4'-difluorobiphenyl 4-(2' 4'-difluorophenyl) acetophenone Friedel-Crafts reaction |
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