Antagonistic effects ofMyxococcus xanthus on fungi: II. Isolation and characterization of inhibitory lipid factors |
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Authors: | Börje Norén Göran Odham |
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Affiliation: | 1. Department of Microbiology, University of Lund, Sweden;2. Lipdi Chemistry Laboratory, University of Göteborg, Sweden |
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Abstract: | The chemical composition of the lipophilic excretion ofMyxococcus xanthus inhibitory to the germination of fungal spores and growth has been investigated. The inhibitory effect was attributed to
a mixture of fungistatically acting fatty acids and a component of antibiotic character. The fatty acid mixture has been fully
characterized and found to constitute a mixture of saturated (68%) and unsaturated (32%) structures in the C13–C17 range. The major part is methylbranched of theiso-type, with 13-methyltetradecanoic acid being the main component (33% of the total). The fungistatic activity of the fatty
acid mixture on spore germination is attributed to the structures withiso-configuration. The presence of unsaturation is of minor importance. Observed morphological changes of the spores and hyphae
in the presence ofiso-fatty acids suggest that they act on the plasma membrane. |
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