Islet transplantation as a treatment for diabetes |
| |
Authors: | GC Weir S Bonner-Weir |
| |
Affiliation: | Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA. |
| |
Abstract: | BACKGROUND: The microvascular complications of diabetes are directly linked to hyperglycemia. Beta-cell failure is a critical factor in regulation of blood sugar levels. However, only a small proportion of persons with type 1 and type 2 diabetes obtain sufficient glycemic control to avoid complications. METHODS: There are two routes for beta-cell replacement, transplantation, and a mechanical beta cell equivalent. Beta-cell replacement therapy is a potential treatment modality, since diabetes is caused by beta-cell failure. RESULTS: An obvious path for glycemic control is some form of beta-cell replacement therapy. Successful islet transplantation is a difficult challenge, but current achievements with human pancreas transplants and islet allografts may greatly improve glycemic control. CONCLUSION: Beta-cell replacement therapy is an accepted treatment modality for diabetes. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|