Green facile synthesis of low-toxic superparamagnetic iron oxide nanoparticles (SPIONs) and their cytotoxicity effects toward Neuro2A and HUVEC cell lines |
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| Authors: | Leila Gholami Reza Kazemi Oskuee Mohsen Tafaghodi Abouzar Ramezani Farkhani Majid Darroudi |
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| Affiliation: | 1. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran;2. Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;4. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | Superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) were synthesized by co-precipitation using polyvinyl alcohol (PVA) as a capping agent under alkaline condition. The produced X-ray diffraction (XRD) pattern evidenced the presence of peaks corresponding to the inverse spinel structure of the prepared SPIONs. Debye-Scherrer and field emission scanning microscopy (FESEM) showed the prepared SPIONs to be well-defined with about in vitro cytotoxicity studies on Neuro2A and HUVEC cells have mentioned low toxic and non-toxic SPIONs, respectively in a range of concentrations (1.17–150?μg/ml), thus, we reckon that the synthesized SPIONs will have persistent utilization in different fields of medical applications. |
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| Keywords: | Iron oxide nanoparticles Superparamagnetic Co-precipitation Cytotoxicity XRD |
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