A novel rapid synthesis,characterization and applications of calcium phosphate nanospheres from Baltic seawater |
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| Authors: | Tao Qin Weiwei Qin Ming Ma Dawei Zhang Shugang Hu Peng Zhang Fredrik Nikolajeff Håkan Engqvist |
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| Affiliation: | 1. Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu 611756, China;2. Department of Engineering Science, Uppsala University, Uppsala 75105, Sweden;3. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;4. Department of Orthopaedics, The Second People''s Hospital of Lianyungang, Lianyungang 222000, China;5. College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China |
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| Abstract: | Due to the considerable high bio-compatibility, calcium phosphate nanoparticles are widely used in biomedical applications. This study proposes a novel strategy for low-cost manufacturing calcium phosphate nanoporous spheres. The controlled reaction only took less than five minutes, when using Baltic seawater with the dissolved calcium concentration of 2.2?mM as the calcium resources. Porous nanospheres were obtained, with spheres ranging from 50 to 130?nm. The obtained nanospheres possess high drug-loading capacity and exhibit sustained release and pH-dependent properties. In addition, this method provides a general efficient strategy to synthesize other low-cost inorganic nanospheres from seawater. |
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| Keywords: | Seawater Nanosphere Low cost Drug Calcium phosphate |
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