The FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer Cells |
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| Authors: | Yu Ran Na Jin Young Kim Chang Ho Song Mikyung Kim Yen Thi Do Tam Thuy Lu Vo Eunsom Choi Eunyoung Ha Ji Hae Seo So-Jin Shin |
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| Affiliation: | 1.Department of Gynecology and Obstetrics, School of Medicine, Keimyung University, Daegu 42601, Korea; (Y.R.N.); (C.H.S.); (Y.T.D.); (E.C.);2.Department of Internal Medicine, Keimyung University School of Medicine, Daegu 42601, Korea;3.Department of Biochemistry, Keimyung University School of Medicine, Daegu 42601, Korea; (M.K.); (T.T.L.V.) |
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| Abstract: | The dysregulation of fibroblast growth factor (FGF) signaling has been implicated in tumorigenesis, tumor progression, angiogenesis, and chemoresistance. The small-molecule AZD4547 is a potent inhibitor of FGF receptors. This study was performed to investigate the antitumor effects and determine the mechanistic details of AZD4547 in ovarian cancer cells. AZD4547 markedly inhibited the proliferation and increased the apoptosis of ovarian cancer cells. AZD4547 also suppressed the migration and invasion of ovarian cancer cells under nontoxic conditions. Furthermore, it attenuated the formation of spheroids and the self-renewal capacities of ovarian cancer stem cells and exerted an antiangiogenic effect. It also suppressed in vivo tumor growth in mice. Collectively, this study demonstrated the antitumor effect of AZD4547 in ovarian cancer cells and suggests that it is a promising agent for ovarian cancer therapy. |
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| Keywords: | AZD4547 cancer stem cells fibroblast growth factor fibroblast growth factor receptor ovarian cancer |
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