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Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum–Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects |
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| Authors: | Monika Hreusova Viktor Brabec Olga Novakova |
| Affiliation: | 1.Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic; (M.H.); (V.B.);2.Department of Biophysics, Faculty of Science, Palacky University, Slechtitelu 27, CZ 78371 Olomouc, Czech Republic |
| Abstract: | |
| Keywords: | cytotoxic antitumor platinum– acridine lesion bypass DNA polymerases thermodynamic microscale thermophoresis translesion synthesis drug resistance metal– intercalator |