Laboratoire de Biophotonique et Pharmacologie, UMR 7213 UdS/CNRS, 74 route du Rhin, 67401 Illkirch, France.
Abstract:
The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.