牛蒡根对单纯型肥胖大鼠护肝、降脂及肝源性血糖异常的改善作用

目的:牛蒡根为一种食药同源原料。本研究探讨牛蒡根对单纯性肥胖大鼠护肝、降脂功能以及调节肝源性血糖异常的作用。方法:建立单纯性肥胖大鼠模型，用牛蒡根粉干预，检测其体质量、摄食量、血液生化指标、脂肪质量与肝脏内的脂质水平(如TG、CHOL等)，并通过HE染色与油红O染色检测肝脏、胰腺的病理变化。结果:在大鼠灌胃牛蒡根第4周，牛蒡根干预组显著抑制肥胖大鼠的体质量增加(P＜0.05)；血清生化指标TG、TCHO、LDL-C、GLU、NEFA等水平均低于造模组大鼠(P＜0.05)；显著减少肥胖大鼠肝脏的脂滴沉积，且肝脏中TG和CHOL含量降低(P＜0.05)，肝脏损伤减轻。牛蒡根干预组的胰腺病理切片结果显示:形态改善至对照组水平，并且可以抑制肥胖大鼠肝源性血糖升高(P＜0.05)。结论:牛蒡根对肥胖大鼠体质量增加具有抑制作用，改善大鼠肝脏脂肪变性，减少肝脏损伤并能有效调节肝源性血糖水平异常。

Effects of Arctium lappa L. Root on Protecting Liver， Reducing Lipids and Hepatogenic Dysglycemia in Simple Obese Rats

Objective: Arctium lappa L. root is a edible food and medicinal material， the purpose of this study was to investigate the effect of burdock root on liver-protecting， lipid-lowering and regulating hepatogenic dysglycemia in simplicity obesity rats. Methods: In this study， the model of simplicity obesity rats was established， intervention treatment by gavage of Arctium lappa L. root powder was carried out. The body weight， food intake， blood biochemical indicators， fat weight and lipid levels in the liver such as TG， CHOL were detected， and the pathological changes of the liver and pancreas were detected by HE staining and oil red O staining. Results: After the 4th week of gavage with Arctium lappa L. root， the intervention group significantly inhibited the weight gain of the obesity rats(P<0.05). The levels of TG， TCHO， LDL-C， GLU， NEFA were lower than those of the model rats (P<0.05)； the intervention of Arctium lappa L. root can significantly reduce the lipid droplet deposition in the liver of obesity rats， and the contents of TG and CHOL in the liver were decreased (P < 0.05)， the liver damage of the obese rats was alleviated； the pancreas pathological section results of the Arctium lappa L. intervention group showed that the morphology was ameliorated to the level of the control group， and it could inhibit the increase of hepatogenic blood glucose in the obese rats(P < 0.05). Conclusion: Arctium lappa L. root has an inhibitory effect on the body weight of obesity rats， ameliorate s liver steatosis， reduces liver damage and can effectively regulate the hepatogenic dysglycemia.