基于聚锑酸的双柱型90Sr-90Y发生器研制

为制备得到大吸附容量、粒径均一、适合色谱柱操作的分离材料，研制出性能优异的⁹⁰Sr-⁹⁰Y发生器，本研究采用真空冷冻干燥法制备吸附性能优异的聚锑酸无机吸附剂作为分离材料，采用双柱法和反载体法分离策略开展⁹⁰Sr-⁹⁰Y发生器研制。系统考察了合成反应条件、干燥方式等因素对聚锑酸制备的影响，获得优化的聚锑酸制备工艺，聚锑酸对锶的静态吸附容量为121 mg/g，吸附平衡时间为4 h，动态吸附容量达到73 mg/g，吸附性能与文献报道相比大幅提高。提出采用双柱法进行Sr、Y分离，以⁸⁹Sr作为示踪剂，向一次柱洗脱液中加入适量Sr反载体后再进行二次柱分离，可使Sr与Y的分离因数提高到10⁷以上，Y的总洗脱效率达77.5%，分离因数满足医用指标要求。本研究针对⁹⁰Sr-⁹⁰Y发生器研制过程中的关键技术问题提出了新的解决思路和方法，并进行了实验验证，对⁹⁰Sr-⁹⁰Y发生器的研制具有重要意义。

Preparation of Double Column Type 90Sr-90Y Generator Based on Polyantimonic Acid

⁹⁰Y is a significant medical radionuclide that can be labeled with monoclonal antibodies, microspheres and peptides for tumor therapy. In this study, inorganic adsorbent polyantimonic acid with excellent adsorption performance was prepared by vacuum freeze-drying method as the separation material, and the ⁹⁰Sr-⁹⁰Y generator was developed by the separation strategy of double column method and hold-back carrier method. The effect of reaction conditions, drying method and other factor on the preparation of polyantimonic acid were systematically investigated, and the optimized preparation process was obtained. The static adsorption capacity of polyantimonic acid for strontium is 121 mg/g, the adsorption equilibrium time is 4 h, and the dynamic adsorption capacity reached 73 mg/g. The adsorption performance of polyantimonic acid was significantly improved compared with previous reports. The separation of Sr and Y was carried out by the double column method with ⁸⁹Sr as tracer, and the separation factor of Sr and Y could be increased to more than 10⁷ after adding Sr hold-back carrier into the primary column eluent. This study puts forward new ideas and methods for the key technical problems in the preparation of ⁹⁰Sr-⁹⁰Y generator, and carries out experimental verification, which is of great significance to the preparation of ⁹⁰Sr-⁹⁰Y generator.