碘催化的葡萄糖异亚丙基缩酮反应研究

以无水葡萄糖为原料、碘为催化剂，催化无水葡萄糖与丙酮的异亚丙基缩酮反应，形成1,2-5,6- 双- 氧-异丙叉- α-D- 呋喃葡萄糖(1,2-5,6-di-O-isopropylidene- α-D-glucofuranose，diacetone glucose，DAG)，并对反应条件进行初步研究。结果表明：碘做催化剂，在回流条件下，5h 能催化葡萄糖与丙酮生成产物DAG；而在低于回流温度反应时，反应时间明显变长。在反应物料最佳物质的量比为葡萄糖:碘:丙酮=1:0.15:122.5 时，最高收率为75% 左右；4A 分子筛的加入并不能显著提高反应收率。

Iodine-Catalyzed Reaction of D-Glucose with Aceton for the Preparation of 1,2-5,6-di-O-Isopropylidene-alpha -Dglucofuranose (DAG)

1,2-5,6-di-O-Isopropylidene-a-D-glucofuranose (DAG), a glucose derivative, was obtained by the reaction of Dglucose with acetone. Effects of various conditions such as temperature, D-glucose/iodine/acetone ratio (molar) and amount of added 4A molecular sieve on production yield of DAG were investigated. In the presence of iodine, heating for 5 h under reflux (at 62 ℃) allowed the generation of DAG from the reaction between D-glucose and acetone. However, the reaction time was greatly extended when the reaction temperature was below 62 ℃. At optimized D-glucose/iodine/acetone ratio of 1:0.15:122.5, the yield of DAG was found to be close to 75%. No obvious effect was found on the yield of DAG with the addition of 4A molecular sieve.