The Synthesis of Pseudo‐Geminal,Pseudo‐Ortho and Ortho Hydroxy‐oxazolinyl[2.2]paracyclophanes for Use as Ligands in Asymmetric Catalysis

Synthetic routes to pseudo‐geminal, pseudo‐ortho and ortho hydroxy‐oxazolinyl[2.2]paracyclophanes (and the diastereoisomers of each) for use as N,O ligands in asymmetric catalysis have been devised. The substitution pattern was found to have a strong effect on the rate and enantioselectivity of the formed catalyst in the addition of diethylzinc to benzaldehyde.