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An Efficient Approach to Chiral Ferrocene‐Based Secondary Alcohols via Asymmetric Hydrogenation of Ferrocenyl Ketones |
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| Authors: | Wing‐Sze Lam Stanton&#x;H&#x;L Kok Terry&#x;T‐L Au‐Yeung Jing Wu Hong‐Yee Cheung Fuk‐Loi Lam Chi‐Hung Yeung Albert&#x;S&#x;C Chan |
| Abstract: | P‐Phos‐ruthenium‐DPEN precatalysts have been found to be efficient for the asymmetric hydrogenation of various ferrocenyl ketones. The use of (R)‐xylyl‐P‐PhosRuCl2(R,R)‐DPEN generated chiral ferrocenylethanol in 99.3% e.e. with >99% conversion in a 150‐g scale. |
| Keywords: | asymmetric catalysis ferrocenyl ketone homogeneous catalysis hydrogenation P‐Phos ruthenium |