| 手性化学工业的发展（一） |
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| 引用本文： | 王普善.手性化学工业的发展（一）[J].精细与专用化学品,2006,14(14):1-5. |
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| 作者姓名： | 王普善 |
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| 作者单位： | 国家食品药品监督管理局信息中心,北京,100810 |
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| 摘 要： | 传统化学仍是获得单一对映体的主要方法,传统化学也可能达到对映体纯产品的目标,例如结晶动力学拆分制备(R)-氟比洛芬,哌啶诱导构型转换制备L-核糖。手性源和拆分方法仍多于催化不对称合成,而催化不对称合成化学的核心是催化剂的选择,不对称环氧化在工业上取得了巨大成功。
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| 关 键 词： | (R)-氟比洛芬 L-核糖 不对称环氧化 |
| 修稿时间： | 2005年12月13 |
Development Trends of Chiral Chemical Industry (Ⅰ) |
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| WANG Pu-shan.Development Trends of Chiral Chemical Industry (Ⅰ)[J].Fine and Specialty Chemicals,2006,14(14):1-5. |
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| Authors: | WANG Pu-shan |
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| Abstract: | The traditional chemistry is still the main method for obtaining single enatiomorph, and it can yield the pure enatiotopic product, e.g. (R)-flubiprofen prepared through crystallization kinetic resolution, L-ribose prepared by induced inversion of configuration based on piperidine. The application of chiral reagent and resolution methods is more than using catalytic asymmetric synthesis. The selection of catalyst is the key problem for catalytic asymmetric synthesis chemistry. However,asymmetric epoxidation has gained great success in commercial production. |
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| Keywords: | (R)-flubiprofen L-ribose asymmetric epoxidation |
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