萘醌芳基化催化反应研究进展

萘醌类化合物由于具有多样生物活性,广泛应用于医药、农药和染料等多相领域,关于萘醌类化合物的合成有很大的研究价值。综述近年来萘醌与各种芳香族化合物的C—C偶联反应的研究报道,包括萘醌与苯硼酸、芳烃、苯基金属卤化物、苯肼和苯胺的芳基化反应等,探讨这些催化反应的反应机理,并比较各种方法的优缺点。现有的合成芳基萘醌的方法存在选择性和收率较低、催化剂不能回收利用和反应液难以分离等缺陷。探索更加绿色环保、催化剂廉价易得且能重复使用的多相催化体系对萘醌芳基化反应的发展具有显著意义。

Research progress in catalytic reaction for arylation of naphthoquinone

Naphthoquinones have been widely applied in medicine,pesticide,dye and other fields due to their various biological activites,so the synthesis of naphthoquinones is of great significance.The study of C-C coupling reaction of naphthoquinones with aromatic compounds in recent years was reviewed,and the reaction mechanisms as well as the advantages and disadvantages of the synthetic methods were discussed in this paper.The arylation reactions,including naphthoquinone with benzeneboronic acid,arene,phenyl metal halide,phenylhydrazine and phenylamine were introduced.The present synthetic methods had the disadvantages of low selectivity,low yield,difficult recycle of catalysts and difficult separation of reaction solution.Therefore,it has notable significance to investigate the green heterogeneous catalytic systems and the catalysts which is cheap, easy to separate and can be repeated use in the development of naphthoquinone arylation.